Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines

BACKGROUND: Human DNA polymerase β (polβ) is a small monomeric protein that is essential for short-patch base excision repair. It plays an important role in regulating the sensitivity of tumor cells to chemotherapy. METHODS: We evaluated the mutation of polβ in a larger cohort of esophageal cancer (...

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Bibliographic Details
Published in:Cancer Cell Int
Main Authors: Wang, Yuanyuan, Chen, Xiaonan, Sun, Qianqian, Zang, Wenqiao, Li, Min, Dong, Ziming, Zhao, Guoqiang
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
Subjects:
Primary Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103481/
https://ncbi.nlm.nih.gov/pubmed/27843412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-016-0362-x
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