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Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines
BACKGROUND: Human DNA polymerase β (polβ) is a small monomeric protein that is essential for short-patch base excision repair. It plays an important role in regulating the sensitivity of tumor cells to chemotherapy. METHODS: We evaluated the mutation of polβ in a larger cohort of esophageal cancer (...
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| Publicado no: | Cancer Cell Int |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5103481/ https://ncbi.nlm.nih.gov/pubmed/27843412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-016-0362-x |
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