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Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice
Exploration of a novel environment leads to neuronal DNA double-strand breaks (DSBs). These DSBs are generated by type 2 topoisomerase to relieve topological constrains that limit transcription of plasticity-related immediate early genes. If not promptly repaired, however, DSBs may lead to cell deat...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5103291/ https://ncbi.nlm.nih.gov/pubmed/27830758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36804 |
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