Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Iα2 expression via miR-342

Insulin promotes bone formation via a well-studied canonical signaling pathway. An adapter in this pathway, insulin-receptor substrate (IRS)-1, has been implicated in the diabetic osteopathy provoked by impaired insulin signaling. To further investigate IRS-1’s role in the bone metabolism, we genera...

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Bibliographische Detailangaben
Veröffentlicht in:FASEB J
Hauptverfasser: Guo, Yue, Tang, Chen-Yi, Man, Xiao-Fei, Tang, Hao-Neng, Tang, Jun, Wang, Fang, Zhou, Ci-La, Tan, Shu-Wen, Feng, Yun-Zhi, Zhou, Hou-De
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102111/
https://ncbi.nlm.nih.gov/pubmed/27623927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600445RR
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