Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex. The human gene contains a polymorphism (Val(158)Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but the findings are mixed. We therefore developed...

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Bibliographic Details
Published in:Neuropsychopharmacology
Main Authors: Barkus, Chris, Korn, Clio, Stumpenhorst, Katharina, Laatikainen, Linda M, Ballard, Dominic, Lee, Sheena, Sharp, Trevor, Harrison, Paul J, Bannerman, David M, Weinberger, Daniel R, Chen, Jingshan, Tunbridge, Elizabeth M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101554/
https://ncbi.nlm.nih.gov/pubmed/27388330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.119
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