Overcoming HBV immune tolerance to eliminate HBsAg-positive hepatocytes via pre-administration of GM-CSF as a novel adjuvant for a hepatitis B vaccine in HBV transgenic mice

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known to be a potential vaccine adjuvant despite contradictory results from animal and human studies. The discrepancies may be due to the different doses and regimens of GM-CSF that were used, given that either mature or immature dendritic...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Wang, Xianzheng, Dong, Aihua, Xiao, Jingjing, Zhou, Xingjun, Mi, Haili, Xu, Hanqian, Zhang, Jiming, Wang, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101445/
https://ncbi.nlm.nih.gov/pubmed/26166767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.64
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