Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication

In eukaryotic DNA replication initiation, hexameric MCM (mini-chromosome maintenance) unwinds the template double-stranded DNA to form the replication fork. MCM is activated by two proteins, Cdc45 and GINS, which constitute the ‘CMG’ unwindosome complex together with the MCM core. The archaeal DNA r...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Oyama, Takuji, Ishino, Sonoko, Shirai, Tsuyoshi, Yamagami, Takeshi, Nagata, Mariko, Ogino, Hiromi, Kusunoki, Masami, Ishino, Yoshizumi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100581/
https://ncbi.nlm.nih.gov/pubmed/27599844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw789
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