Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway

BACKGROUND: Tumor suppressive let-7 miRNAs are universally down-regulated in human hepatocellular carcinoma (HCC) versus normal tissues; however, the roles and related molecular mechanisms of let-7 in HCC stem cells are poorly understood. METHODS: We examined the inhibitory effect of let-7 miRNAs on...

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Опубликовано в: :BMC Cancer
Главные авторы: Jin, Bin, Wang, Wei, Meng, Xiang-xin, Du, Gang, Li, Jia, Zhang, Shi-zhe, Zhou, Bing-hai, Fu, Zhi-hao
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100284/
https://ncbi.nlm.nih.gov/pubmed/27821157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2904-y
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