Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients

BACKGROUND: The majority of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation eventually develop resistance to EGFR tyrosine kinase inhibitors (TKIs). Minimal information exists regarding genetic alterations in rebiopsy samples from Asian NSCLC patient...

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Dades bibliogràfiques
Publicat a:BMC Cancer
Autors principals: Ko, Ryo, Kenmotsu, Hirotsugu, Serizawa, Masakuni, Koh, Yasuhiro, Wakuda, Kazushige, Ono, Akira, Taira, Tetsuhiko, Naito, Tateaki, Murakami, Haruyasu, Isaka, Mitsuhiro, Endo, Masahiro, Nakajima, Takashi, Ohde, Yasuhisa, Yamamoto, Nobuyuki, Takahashi, Kazuhisa, Takahashi, Toshiaki
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100094/
https://ncbi.nlm.nih.gov/pubmed/27821131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2902-0
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