Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients

BACKGROUND: The majority of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation eventually develop resistance to EGFR tyrosine kinase inhibitors (TKIs). Minimal information exists regarding genetic alterations in rebiopsy samples from Asian NSCLC patient...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Ko, Ryo, Kenmotsu, Hirotsugu, Serizawa, Masakuni, Koh, Yasuhiro, Wakuda, Kazushige, Ono, Akira, Taira, Tetsuhiko, Naito, Tateaki, Murakami, Haruyasu, Isaka, Mitsuhiro, Endo, Masahiro, Nakajima, Takashi, Ohde, Yasuhisa, Yamamoto, Nobuyuki, Takahashi, Kazuhisa, Takahashi, Toshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100094/
https://ncbi.nlm.nih.gov/pubmed/27821131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2902-0
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