Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons

AIM: Iron dyshomeostasis is one of the primary causes of neuronal death in Alzheimer's disease (AD). Huperzine A (HupA), a natural inhibitor of acetylcholinesterase (AChE), is a licensed anti-AD drug in China and a nutraceutical in the United Sates. Here, we investigated the protective effects...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Tao, Ling-xue, Huang, Xiao-tian, Chen, Yu-ting, Tang, Xi-can, Zhang, Hai-yan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099413/
https://ncbi.nlm.nih.gov/pubmed/27498774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.78
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