Thymocytes in Lyve1-CRE/S1pr1(f/f) Mice Accumulate in the Thymus due to Cell-Intrinsic Loss of Sphingosine-1-Phosphate Receptor Expression

T cell emigration from the thymus is essential for immunological homeostasis. While stromal cell-produced sphingosine-1-phosphate (S1P) has been shown to promote thymocyte egress via the S1P receptor, S1PR1, the significance of S1P/S1PR1 signaling in the thymic stromal cells that surround T cells re...

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Udgivet i:Front Immunol
Main Authors: Takeda, Akira, Hossain, Mohammad Shahadat, Rantakari, Pia, Simmons, Szandor, Sasaki, Naoko, Salmi, Marko, Jalkanen, Sirpa, Miyasaka, Masayuki
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099144/
https://ncbi.nlm.nih.gov/pubmed/27877175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00489
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