Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury

The delayed rectifier potassium (K(+)) channel KCNB1 (Kv2.1), which conducts a major somatodendritic current in cortex and hippocampus, is known to undergo oxidation in the brain, but whether this can cause neurodegeneration and cognitive impairment is not known. Here, we used transgenic mice harbor...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Yu, Wei, Parakramaweera, Randika, Teng, Shavonne, Gowda, Manasa, Sharad, Yashsavi, Thakker-Varia, Smita, Alder, Janet, Sesti, Federico
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2016
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098843/
https://ncbi.nlm.nih.gov/pubmed/27798188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2273-16.2016
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