Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury

The delayed rectifier potassium (K(+)) channel KCNB1 (Kv2.1), which conducts a major somatodendritic current in cortex and hippocampus, is known to undergo oxidation in the brain, but whether this can cause neurodegeneration and cognitive impairment is not known. Here, we used transgenic mice harbor...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Yu, Wei, Parakramaweera, Randika, Teng, Shavonne, Gowda, Manasa, Sharad, Yashsavi, Thakker-Varia, Smita, Alder, Janet, Sesti, Federico
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2016
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098843/
https://ncbi.nlm.nih.gov/pubmed/27798188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2273-16.2016
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