Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury

The delayed rectifier potassium (K(+)) channel KCNB1 (Kv2.1), which conducts a major somatodendritic current in cortex and hippocampus, is known to undergo oxidation in the brain, but whether this can cause neurodegeneration and cognitive impairment is not known. Here, we used transgenic mice harbor...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Yu, Wei, Parakramaweera, Randika, Teng, Shavonne, Gowda, Manasa, Sharad, Yashsavi, Thakker-Varia, Smita, Alder, Janet, Sesti, Federico
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098843/
https://ncbi.nlm.nih.gov/pubmed/27798188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2273-16.2016
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