Capture of micrococcin biosynthetic intermediates reveals C-terminal processing as an obligatory step for in vivo maturation

Thiopeptides, including micrococcins, are a growing family of bioactive natural products that are ribosomally synthesized and heavily modified. Here we use a refactored, modular in vivo system containing the micrococcin P1 (MP1) biosynthetic genes (TclIJKLMNPS) from Macrococcus caseolyticus str 115...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Bewley, Kathryn D., Bennallack, Philip R., Burlingame, Mark A., Robison, Richard A., Griffitts, Joel S., Miller, Susan M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098666/
https://ncbi.nlm.nih.gov/pubmed/27791142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612161113
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires