Capture of micrococcin biosynthetic intermediates reveals C-terminal processing as an obligatory step for in vivo maturation

Thiopeptides, including micrococcins, are a growing family of bioactive natural products that are ribosomally synthesized and heavily modified. Here we use a refactored, modular in vivo system containing the micrococcin P1 (MP1) biosynthetic genes (TclIJKLMNPS) from Macrococcus caseolyticus str 115...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Bewley, Kathryn D., Bennallack, Philip R., Burlingame, Mark A., Robison, Richard A., Griffitts, Joel S., Miller, Susan M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098666/
https://ncbi.nlm.nih.gov/pubmed/27791142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612161113
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