Structural elements of an NRPS cyclization domain and its intermodule docking domain

Epothilones are thiazole-containing natural products with anticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA–F. A cyclization domain of EpoB (Cy) assembles the thiazole functionality from an acetyl group and l-cysteine via con...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Dowling, Daniel P., Kung, Yan, Croft, Anna K., Taghizadeh, Koli, Kelly, Wendy L., Walsh, Christopher T., Drennan, Catherine L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098645/
https://ncbi.nlm.nih.gov/pubmed/27791103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608615113
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