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How Does the Methodology of 3D Structure Preparation Influence the Quality of pK(a) Prediction?

The acid dissociation constant is an important molecular property and it can be successfully predicted by Quantitative Structure-Property Relationship (QSPR) models, even for in silico designed molecules. We analyzed how the methodology of in silico 3D structure preparation influences the quality of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Chem Inf Model
Prif Awduron: Geidl, Stanislav, Vařeková, Radka Svobodová, Bendová, Veronika, Petrusek, Lukáš, Ionescu, Crina-Maria, Jurka, Zdeněk, Abagyan, Ruben, Koča, Jaroslav
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098400/
https://ncbi.nlm.nih.gov/pubmed/26010215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci500758w
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