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Small-Volume Adenosine, Lidocaine, and Mg(2+) 4-Hour Infusion Leads to 88% Survival after 6 Days of Experimental Sepsis in the Rat without Antibiotics
Innovative host-directed drug therapies are urgently required to treat sepsis. We tested the effect of a small-volume 0.9% NaCl adenosine, lidocaine, and Mg(2+) (ALM) bolus and a 4-h intravenous infusion on survivability in the rat model of polymicrobial sepsis over 6 days. ALM treatment led to a si...
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| Publicado no: | Clin Vaccine Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5098019/ https://ncbi.nlm.nih.gov/pubmed/27581435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00390-16 |
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