Apolipoprotein E4 causes age-dependent disruption of slow gamma oscillations during hippocampal sharp-wave ripples

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease (AD), but the mechanism by which it causes cognitive decline is unclear. In knock-in (KI) mice, human apoE4 causes age-dependent learning and memory impairments and degeneration of GABAergic interneurons in the hippocam...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Gillespie, Anna K., Jones, Emily A., Lin, Yuan-Hung, Karlsson, Mattias P., Kay, Kenneth, Yoon, Seo Yeon, Tong, Leslie M., Nova, Philip, Carr, Jessie S., Frank, Loren M., Huang, Yadong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097044/
https://ncbi.nlm.nih.gov/pubmed/27161522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.04.009
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados