Cyclin F-mediated degradation of SLBP limits H2A.X accumulation and apoptosis upon genotoxic stress in G2

SLBP (stem-loop binding protein) is a highly conserved factor necessary for the processing, translation, and degradation of H2AFX and canonical histone mRNAs. We identified the F-box protein cyclin F, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box protein) complex, as the G2 ubiquitin li...

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Foilsithe in:Mol Cell
Main Authors: Dankert, John F., Rona, Gergely, Clijsters, Linda, Geter, Phillip, Skaar, Jeffrey R., Bermudez-Hernandez, Keria, Sassani, Elizabeth, Fenyö, David, Ueberheide, Beatrix, Schneider, Robert, Pagano, Michele
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097008/
https://ncbi.nlm.nih.gov/pubmed/27773672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.09.010
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