Matricellular protein SPARCL1 regulates tumor microenvironment–dependent endothelial cell heterogeneity in colorectal carcinoma

Different tumor microenvironments (TMEs) induce stromal cell plasticity that affects tumorigenesis. The impact of TME-dependent heterogeneity of tumor endothelial cells (TECs) on tumorigenesis is unclear. Here, we isolated pure TECs from human colorectal carcinomas (CRCs) that exhibited TMEs with ei...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Naschberger, Elisabeth, Liebl, Andrea, Schellerer, Vera S., Schütz, Manuela, Britzen-Laurent, Nathalie, Kölbel, Patrick, Schaal, Ute, Haep, Lisa, Regensburger, Daniela, Wittmann, Thomas, Klein-Hitpass, Ludger, Rau, Tilman T., Dietel, Barbara, Méniel, Valérie S., Clarke, Alan R., Merkel, Susanne, Croner, Roland S., Hohenberger, Werner, Stürzl, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096916/
https://ncbi.nlm.nih.gov/pubmed/27721236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78260
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