Cancer-associated fibroblast-derived annexin A6(+) extracellular vesicles support pancreatic cancer aggressiveness

The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA), and specific conditions in the stroma may promote increased cancer aggressiveness. We hypothesized that this heterogeneous and evolving compartment drastically influenc...

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Udgivet i:J Clin Invest
Main Authors: Leca, Julie, Martinez, Sébastien, Lac, Sophie, Nigri, Jérémy, Secq, Véronique, Rubis, Marion, Bressy, Christian, Sergé, Arnauld, Lavaut, Marie-Noelle, Dusetti, Nelson, Loncle, Céline, Roques, Julie, Pietrasz, Daniel, Bousquet, Corinne, Garcia, Stéphane, Granjeaud, Samuel, Ouaissi, Mehdi, Bachet, Jean Baptiste, Brun, Christine, Iovanna, Juan L., Zimmermann, Pascale, Vasseur, Sophie, Tomasini, Richard
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096915/
https://ncbi.nlm.nih.gov/pubmed/27701147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87734
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