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Aging promotes acquisition of naive-like CD8(+) memory T cell traits and enhanced functionalities

Protective T cell memory is an acquired trait that is contingent upon the preservation of its constituents and therefore vulnerable to the potentially deleterious effects of organismal aging. Here, however, we have found that long-term T cell memory in a natural murine host-pathogen system can subst...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Eberlein, Jens, Davenport, Bennett, Nguyen, Tom, Victorino, Francisco, Haist, Kelsey, Jhun, Kevin, Karimpour-Fard, Anis, Hunter, Lawrence, Kedl, Ross, Clambey, Eric T., Homann, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096808/
https://ncbi.nlm.nih.gov/pubmed/27617858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88546
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