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1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization
Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases....
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| Publicado no: | Adv Sci (Weinh) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5096251/ https://ncbi.nlm.nih.gov/pubmed/27840798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201600082 |
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