Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: MECHANISTIC DETAILS STUDIED BY SPECTROSCOPY IN COMBINATION WITH MICROSCOPY

The aggregation of insulin into amyloid fibers has been a limiting factor in the development of fast acting insulin analogues, creating a demand for excipients that limit aggregation. Despite the potential demand, inhibitors specifically targeting insulin have been few in number. Here we report a no...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ratha, Bhisma N., Ghosh, Anirban, Brender, Jeffrey R., Gayen, Nilanjan, Ilyas, Humaira, Neeraja, Chilukoti, Das, Kali P., Mandal, Atin K., Bhunia, Anirban
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095409/
https://ncbi.nlm.nih.gov/pubmed/27679488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.742460
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