Physiological Expression of AMPKγ2(RG) Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice

Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2(NI)) and R531G (AMPKγ2(RG)), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2(NI...

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發表在:J Biol Chem
Main Authors: Yang, Xiaodong, Mudgett, John, Bou-About, Ghina, Champy, Marie-France, Jacobs, Hugues, Monassier, Laurent, Pavlovic, Guillaume, Sorg, Tania, Herault, Yann, Petit-Demoulière, Benoit, Lu, Ku, Feng, Wen, Wang, Hongwu, Ma, Li-Jun, Askew, Roger, Erion, Mark D., Kelley, David E., Myers, Robert W., Li, Cai, Guan, Hong-Ping
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2016
主題:
Metabolism
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095399/
https://ncbi.nlm.nih.gov/pubmed/27621313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738591
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