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The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer

The stability and integrity of the human genome are maintained by the DNA damage repair (DDR) system. Unrepaired DNA damage is a major source of potentially mutagenic lesions that drive carcinogenesis. In addition to gene mutation, DNA methylation occurs more frequently in DDR genes in human cancer....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gao, Dan, Herman, James G., Guo, Mingzhou
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095080/
https://ncbi.nlm.nih.gov/pubmed/26967246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7949
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