CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPARγ pathway

Cyclin-dependent kinase 5 (CDK5) has been documented in podocyte injuries in diabetic nephropathy (DN), however its role in renal tubular epithelial cells has not been elucidated. We report here that CDK5 is detrimental and promotes tubulointerstitial fibrosis (TIF) via the extracellular signal-regu...

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Vydáno v:Oncotarget
Hlavní autoři: Bai, Xiaoyan, Hou, Xiaoyan, Tian, Jianwei, Geng, Jian, Li, Xiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095017/
https://ncbi.nlm.nih.gov/pubmed/27145370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9058
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