Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation and apoptosis in diabetic cardiomyopathy

Diabetic cardiomyopathy (DCM) is characterized by structural alterations such as cardiomyocyte hypertrophy, necrosis and focal fibrosis. Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme which can be activated by DNA damage and plays a critical role in various diseases. We hypothesized that...

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Pubblicato in:Oncotarget
Autori principali: Qin, Wei-dong, Liu, Guo-liang, Wang, Juan, Wang, Hao, Zhang, Jian-ning, Zhang, Fan, Ma, Yang, Ji, Xin-ying, Li, Chen, Zhang, Ming-xiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper: Pathology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094949/
https://ncbi.nlm.nih.gov/pubmed/27027354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8343
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