Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses

It is well established that the formation of transthyretin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric structure into insoluble aggregates. Isotope labeling is used for the study of TTR by NMR, neutron diffraction, and mass spectrometry (MS). Here MS, th...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Angew Chem Int Ed Engl
मुख्य लेखकों: Yee, Ai Woon, Moulin, Martine, Breteau, Nina, Haertlein, Michael, Mitchell, Edward P., Cooper, Jonathan B., Boeri Erba, Elisabetta, Forsyth, V. Trevor
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley and Sons Inc. 2016
विषय:
Communications
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094506/
https://ncbi.nlm.nih.gov/pubmed/27311939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201602747
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