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A systematic ensemble approach to thermodynamic modeling reveals an enhancer’s logic
To understand the relationship between enhancer DNA sequence and quantitative gene expression, thermodynamics-driven mathematical models of transcription are often employed. These “sequence-to-expression” models can describe an incomplete or even incorrect set of regulatory relationships if paramete...
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| Опубликовано в: : | Cell Syst |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5094195/ https://ncbi.nlm.nih.gov/pubmed/27136354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2015.12.002 |
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