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Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX

Administration of exogenous 5-aminolevulinic acid (5-ALA) to cancerous tissue leads to intracellular production of photoactive protoporphyrin IX, a biosynthetic process that enables photodynamic therapy and fluorescence-guided surgery of cancer. Cell uptake of 5-ALA is limited by its polar structure...

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Publicado en:Photochem Photobiol Sci
Main Authors: Harmatys, Kara M., Musso, Anthony J., Clear, Kasey J., Smith, Bradley D.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093051/
https://ncbi.nlm.nih.gov/pubmed/27722428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6pp00151c
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