Self-antigen-driven thymic B cell class switching promotes T cell central tolerance

B cells are unique antigen presenting cells because their antigen presentation machinery is closely tied to the B cell receptor. Autoreactive thymic B cells can efficiently present cognate self-antigens to mediate CD4(+) T cell negative selection. However, the nature of thymocyte-thymic B cell inter...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Perera, Jason, Zheng, Zhong, Li, Shuyin, Gudjonson, Herman, Kalinina, Olga, Benichou, Jennifer I. C., Block, Katharine E., Louzoun, Yoram, Yin, Dengping, Chong, Anita S., Dinner, Aaron R., Weigert, Martin, Huang, Haochu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5091085/
https://ncbi.nlm.nih.gov/pubmed/27705788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.011
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