Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis

OBJECTIVES: Esculetin (6,7-dihydroxycoumarin) is a natural coumarin with anti-oxidant, anti-inflammatory and anti-nociceptive activity. It acts as a potent inhibitor of lipoxygenases (5-LOX and 12-LOX) and decreases the production of matrix metalloproteinases (MMP-1, MMP-3 and MMP-9). Because both i...

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Bibliografiske detaljer
Udgivet i:Reumatologia
Main Authors: Rzodkiewicz, Przemysław, Gąsińska, Emilia, Gajewski, Michał, Bujalska-Zadrożny, Magdalena, Szukiewicz, Dariusz, Maśliński, Sławomir
Format: Artigo
Sprog:Inglês
Udgivet: Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2016
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090023/
https://ncbi.nlm.nih.gov/pubmed/27826169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/reum.2016.62469
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