Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice.

Hypertrophic cardiomyopathy (HCM) is a disease of sarcomeric proteins. The mechanism by which mutant sarcomeric proteins cause HCM is unknown. The leading hypothesis proposes that mutant sarcomeric proteins exert a dominant-negative effect on myocyte structure and function. To test this, we produced...

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Detalhes bibliográficos
Main Authors: Oberst, L, Zhao, G, Park, J T, Brugada, R, Michael, L H, Entman, M L, Roberts, R, Marian, A J
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508999/
https://ncbi.nlm.nih.gov/pubmed/9788962
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