The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

Beta1- and beta2-adrenoceptors in heart muscle cells mediate the catecholamine-induced increase in the force and frequency of cardiac contraction. Recently, in addition, we demonstrated the functional expression of beta3-adrenoceptors in the human heart. Their stimulation, in marked contrast with th...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Gauthier, C, Leblais, V, Kobzik, L, Trochu, J N, Khandoudi, N, Bril, A, Balligand, J L, Le Marec, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508985/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9769330/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2191
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