Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia.

Congenital hyperinsulinism, or persistent hyperinsulinemic hypoglycemia of infancy (PHHI), is a glucose metabolism disorder characterized by unregulated secretion of insulin and profound hypoglycemia. From a morphological standpoint, there are two types of histopathological lesions, a focal adenomat...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Verkarre, V, Fournet, J C, de Lonlay, P, Gross-Morand, M S, Devillers, M, Rahier, J, Brunelle, F, Robert, J J, Nihoul-Fékété, C, Saudubray, J M, Junien, C
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508975/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9769320/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4495
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