Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

The cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is characterized by increased concentrations of immunoglobulin (Ig), which on electrophoretic analysis shows restricted heterogeneity (oligoclonal bands). CSF Ig is composed of both serum and intrathecally produced components. To exam...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Qin, Y, Duquette, P, Zhang, Y, Talbot, P, Poole, R, Antel, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9727074/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI3568
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