Identification of novel bile acids as biomarkers for the early diagnosis of Niemann‐Pick C disease

This article describes a rapid UPLC‐MS/MS method to quantitate novel bile acids in biological fluids and the evaluation of their diagnostic potential in Niemann‐Pick C (NPC). Two new compounds, NPCBA1 (3β‐hydroxy,7β‐N‐acetylglucosaminyl‐5‐cholenoic acid) and NPCBA2 (probably 3β,5α,6β‐trihydroxychola...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Mazzacuva, Francesca, Mills, Philippa, Mills, Kevin, Camuzeaux, Stephane, Gissen, Paul, Nicoli, Elena‐Raluca, Wassif, Christopher, te Vruchte, Danielle, Porter, Forbes D., Maekawa, Masamitsu, Mano, Nariyasu, Iida, Takashi, Platt, Frances, Clayton, Peter T.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Letters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089630/
https://ncbi.nlm.nih.gov/pubmed/27139891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12196
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