GM(1) Ganglioside Inhibits β‐Amyloid Oligomerization Induced by Sphingomyelin

β‐Amyloid (Aβ) oligomers are neurotoxic and implicated in Alzheimer's disease. Neuronal plasma membranes may mediate formation of Aβ oligomers in vivo. Membrane components sphingomyelin and GM(1) have been shown to promote aggregation of Aβ; however, these studies were performed under extreme,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Angew Chem Int Ed Engl
Prif Awduron: Amaro, Mariana, Šachl, Radek, Aydogan, Gokcan, Mikhalyov, Ilya I., Vácha, Robert, Hof, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Communications
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089616/
https://ncbi.nlm.nih.gov/pubmed/27295499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201603178
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