Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition.

Oxygen deprivation, as occurs during tissue ischemia, tips the natural anticoagulant/procoagulant balance of the endovascular wall to favor activation of coagulation. To investigate the effects of low ambient oxygen tension on the fibrinolytic system, mice were placed in a hypoxic environment with p...

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Detalhes bibliográficos
Main Authors: Pinsky, D J, Liao, H, Lawson, C A, Yan, S F, Chen, J, Carmeliet, P, Loskutoff, D J, Stern, D M
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508957/
https://ncbi.nlm.nih.gov/pubmed/9727060
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