Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition.

Oxygen deprivation, as occurs during tissue ischemia, tips the natural anticoagulant/procoagulant balance of the endovascular wall to favor activation of coagulation. To investigate the effects of low ambient oxygen tension on the fibrinolytic system, mice were placed in a hypoxic environment with p...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Pinsky, D J, Liao, H, Lawson, C A, Yan, S F, Chen, J, Carmeliet, P, Loskutoff, D J, Stern, D M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508957/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9727060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI307
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