PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.

Osteoclast activation is initiated by adhesion to the bone surface, followed by cytoskeletal rearrangement, the formation of the sealing zone, and a polarized ruffled membrane. This study shows that PYK2/CAKbeta/RAFTK, a cytoplasmic kinase related to the focal adhesion kinase, is highly expressed in...

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Main Authors: Duong, L T, Lakkakorpi, P T, Nakamura, I, Machwate, M, Nagy, R M, Rodan, G A
Formato: Artigo
Idioma:Inglês
Publicado: 1998
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC508953/
https://ncbi.nlm.nih.gov/pubmed/9727056
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