Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

A soluble monomeric form of Alzheimer's amyloid-beta (1-40) peptide (sAbeta1-40) is present in the circulation and could contribute to neurotoxicity if it crosses the brain capillary endothelium, which comprises the blood-brain barrier (BBB) in vivo. This study characterizes endothelial binding...

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Bibliographische Detailangaben
Hauptverfasser: Mackic, J B, Stins, M, McComb, J G, Calero, M, Ghiso, J, Kim, K S, Yan, S D, Stern, D, Schmidt, A M, Frangione, B, Zlokovic, B V
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1998
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC508936/
https://ncbi.nlm.nih.gov/pubmed/9710442
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