Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

Liver fibrosis results from the excessive secretion of matrix proteins by hepatic stellate cells (HSC), which proliferate during fibrotic liver injury. We have studied a model of spontaneous recovery from liver fibrosis to determine the biological mechanisms mediating resolution. Livers were harvest...

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Detalhes bibliográficos
Main Authors: Iredale, J P, Benyon, R C, Pickering, J, McCullen, M, Northrop, M, Pawley, S, Hovell, C, Arthur, M J
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508915/
https://ncbi.nlm.nih.gov/pubmed/9691091
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