Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive. METHODS: To elucidate mol...

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Pubblicato in:Genome Med
Autori principali: Wang, Minghui, Roussos, Panos, McKenzie, Andrew, Zhou, Xianxiao, Kajiwara, Yuji, Brennand, Kristen J., De Luca, Gabriele C., Crary, John F., Casaccia, Patrizia, Buxbaum, Joseph D., Ehrlich, Michelle, Gandy, Sam, Goate, Alison, Katsel, Pavel, Schadt, Eric, Haroutunian, Vahram, Zhang, Bin
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088659/
https://ncbi.nlm.nih.gov/pubmed/27799057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0355-3
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