Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

Compaction of chromosomes is essential for accurate segregation of the genome during mitosis. In vertebrates, two condensin complexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic chromosome structure. Here, we report that biallelic mutations in...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Martin, Carol-Anne, Murray, Jennie E., Carroll, Paula, Leitch, Andrea, Mackenzie, Karen J., Halachev, Mihail, Fetit, Ahmed E., Keith, Charlotte, Bicknell, Louise S., Fluteau, Adeline, Gautier, Philippe, Hall, Emma A., Joss, Shelagh, Soares, Gabriela, Silva, João, Bober, Michael B., Duker, Angela, Wise, Carol A., Quigley, Alan J., Phadke, Shubha R., Wood, Andrew J., Vagnarelli, Paola, Jackson, Andrew P.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088565/
https://ncbi.nlm.nih.gov/pubmed/27737959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.286351.116
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