Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance.

Insulin resistance is instrumental in the pathogenesis of type 2 diabetes mellitus and the Insulin Resistance Syndrome. While insulin resistance involves decreased glucose transport activity in skeletal muscle, its molecular basis is unknown. Since muscle GLUT4 glucose transporter levels are normal...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Garvey, W T, Maianu, L, Zhu, J H, Brechtel-Hook, G, Wallace, P, Baron, A D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508827/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9616209/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1557
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