Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.

Transgenic rabbits expressing human apo E3 were generated to investigate mechanisms by which apo E modulates plasma lipoprotein metabolism. Compared with nontransgenic littermates expressing approximately 3 mg/dl of endogenous rabbit apo E, male transgenic rabbits expressing approximately 13 mg/dl o...

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Bibliographic Details
Main Authors: Fan, J, Ji, Z S, Huang, Y, de Silva, H, Sanan, D, Mahley, R W, Innerarity, T L, Taylor, J M
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC508803/
https://ncbi.nlm.nih.gov/pubmed/9593771
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