Detection of CYP2C19 Genetic Variants in Malaysian Orang Asli from Massively Parallel Sequencing Data

The human cytochrome P450 (CYP) is a superfamily of enzymes that have been a focus in research for decades due to their prominent role in drug metabolism. CYP2C is one of the major subfamilies which metabolize more than 10% of all clinically used drugs. In the context of CYP2C19, several key genetic...

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Vydáno v:PLoS One
Hlavní autoři: Ang, Geik Yong, Yu, Choo Yee, Subramaniam, Vinothini, Abdul Khalid, Mohd Ikhmal Hanif, Tuan Abdu Aziz, Tuan Azlin, Johari James, Richard, Ahmad, Aminuddin, Abdul Rahman, Thuhairah, Mohd Nor, Fadzilah, Ismail, Adzrool Idzwan, Md. Isa, Kamarudzaman, Salleh, Hood, Teh, Lay Kek, Salleh, Mohd Zaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087908/
https://ncbi.nlm.nih.gov/pubmed/27798644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164169
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