Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.

Acute lung injury is a frequent and treatment-limiting consequence of therapy with hyperoxic gas mixtures. To determine if IL-11 is protective in oxygen toxicity, we compared the effects of 100% O2 on transgenic mice that overexpress IL-11 in the lung and transgene (-) controls. IL-11 markedly enhan...

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Publicat a:J Clin Invest
Autors principals: Waxman, A B, Einarsson, O, Seres, T, Knickelbein, R G, Warshaw, J B, Johnston, R, Homer, R J, Elias, J A
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1998
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508784/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9576762/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1337
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