Selective Assembly of Na,K-ATPase α(2)β(2) Heterodimers in the Heart: DISTINCT FUNCTIONAL PROPERTIES AND ISOFORM-SELECTIVE INHIBITORS

The Na,K-ATPase α(2) subunit plays a key role in cardiac muscle contraction by regulating intracellular Ca(2+), whereas α(1) has a more conventional role of maintaining ion homeostasis. The β subunit differentially regulates maturation, trafficking, and activity of α-β heterodimers. It is not known...

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Vydáno v:J Biol Chem
Hlavní autoři: Habeck, Michael, Tokhtaeva, Elmira, Nadav, Yotam, Ben Zeev, Efrat, Ferris, Sean P., Kaufman, Randal J., Bab-Dinitz, Elizabeta, Kaplan, Jack H., Dada, Laura A., Farfel, Zvi, Tal, Daniel M., Katz, Adriana, Sachs, George, Vagin, Olga, Karlish, Steven J. D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087734/
https://ncbi.nlm.nih.gov/pubmed/27624940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.751735
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