Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation

Centrosomes are major microtubule-organizing centers composed of centrioles surrounded by an extensive proteinacious layer called the pericentriolar material (PCM). In Caenorhabditis elegans embryos, the mitotic PCM expands by Polo-like kinase 1 (PLK-1) phosphorylation-accelerated assembly of SPD-5...

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Bibliografiske detaljer
Udgivet i:Biol Open
Main Authors: Wueseke, Oliver, Zwicker, David, Schwager, Anne, Wong, Yao Liang, Oegema, Karen, Jülicher, Frank, Hyman, Anthony A., Woodruff, Jeffrey B.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087692/
https://ncbi.nlm.nih.gov/pubmed/27591191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.020990
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